Matthew C. “Matt” Iseman (born January 22, 1971) is an American comedian, actor, and television host, who began his career as a physician. Iseman has hosted the game shows Scream Play on E! and Casino Night on the GSN. He appears as a regular cast member on the home makeover show Clean House and its companion outtakes show, Clean House Comes Clean, both on the Style Network. Additionally, he hosted seasons 2 and 3 of American Ninja Warrior on the channel G4. Iseman began working with American Ninja Warrior in 2010. He uses his athleticism and work as a comedian to add his style to the show with Akbar Gbaja-Biamila (former American professional football player), and Jenn Brown (sideline correspondent). He also has worked episodically in television shows including The Drew Carey Show, NCIS, and General Hospital. He has appeared on the syndicated MAD TV, Comedy Central’s Premium Blend, Fox’s The Best Damn Sports Show Period, and Fox News Channel’s Red Eye w/ Greg Gutfeld.As of May 4, 2010, Iseman is the host of Sports Soup, a spin-off of E!’s The Soup, on Versus. Style Network and Versus are owned by Comcast.